scholarly journals Central nervous system granulocytic sarcoma in a patient with essential thrombocythemia

1996 ◽  
Vol 51 (1) ◽  
pp. 64-67 ◽  
Author(s):  
Mario Grande
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Essential Thrombocythemia ◽  
Granulocytic Sarcoma

Evaluation of the Oncohaematologic Pathology of Two Oncologics Centers of Buenos Aires, Argentina in the Period between 1995–2005; a Total of 1884 Cases.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4683-4683
Author(s):  
Marta O. Dragosky ◽  
Isabel Annetta ◽  
Viviana Alvarellos4 ◽  
Laura Devotto5 ◽  
Patricia Luchetta6 ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Thyroid Gland ◽  
Hodgkin Lymphoma ◽  
Soft Tissues ◽  
Buenos Aires ◽  
Low Frequency ◽  
Granulocytic Sarcoma ◽  
Sex Distribution ◽  
Non Hodgkin Lymphoma

Abstract Introduction: In the absence of national and regional records of oncohaematologic pathology the information regarding the composition and characterstics of this patients population was evaluated in this two oncologic centers of Buenos Aires. Results: Of the whole of 1884 patients, the distribution of the pathologies was: Non Hodgkin Lymphoma (NHL): 1040 cases (55,2 %), Hodgkin Lymphoma (HL) 358 (19 %), Leukemia 258 (13,7 %), (chronic lymphatic 105, chronic myeloid 93, acute 52, trycholeukemia 8) Myeloma 131 (6,95 %), thrombocythemia 24 (1,27 %), Myelodysplasia 22 (1,16 %), Polycythemia Vera: 17 (0,90 %), Plasmacytoma 14 (0,74 %), Myelofibrosis 8 (0,42 %), Histiocytosis. 5 (0,26 %), Macroglobulinemia of Waldenstrom 4 (0,2 %), Granulocytic Sarcoma 2 (0,1 %), Dendritics Cells Sarcoma 1 (0,05 %). The sex distribution was: 982 (52.14 %) males, 902 (47,86 %) females. The range of ages was: 15 to 94 years, with an average of 52,3 years. Of the whole of 1040 NHL 274 (26,34 %) presented extranodal locations, distributed as follows: skin 63, orbital 37, tonsil 35, oral cavity 17, stomach 16, central nervous system 16 (12 brain), breast 13, soft tissues 12, parothyd 11, cavum 11, bowel 9, testicle 7, paranasal sinuses and bones 6, rectum and lung 3, larynx, uterus and scalp 2, liver, ovary and thyroid gland 1. A whole of 29 patients presented pathology associated with the HIV: 22 NHL and 7 HL. In the population with HL the average age was 36,7 years, with 38 % younger than 25 years, we do not observe the bimodal curve usually descript. The predominant histologies: nodular sclerosis 40,7 % and mixed cellularity36,53 % (low frequency of subtypes lymphocitary predominance and lymphocitary depletion). Stage II 44,87 % and stage III 23,71 %. The most frequent locations: cervical 53,2 % and mediastinic 47,11 % (and low frequency of abdominal and inguinal locations). Conclusions: The frequency of extranodal locations of NHL is similar as the international records. The distribution of the unusual locations is probably biased by the pathologies arrived from specific centers (for example: a center of ophthalmology). The population of HL is characterized by the young age and the supradiaphragmatic locations

Granulocytic sarcoma of the central nervous system: Inital presentation of leukemia

1978 ◽  
Vol 42 (2) ◽  
pp. 145-147 ◽  
Author(s):  
J. F. Llena ◽  
K. Kawamoto ◽  
A. Hirano ◽  
E. H. Feiring
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Granulocytic Sarcoma ◽  
The Central Nervous System

scholarly journals Primary Granulocytic Sarcoma of Cervix (PGSC): Review and Analysis of 13 Cases

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 5271-5271
Author(s):  
Xuelan Zuo ◽  
Ying Wang ◽  
Yi Zhou ◽  
Lin Luo ◽  
Minghui Liu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Combination Therapy ◽  
Intrathecal Injection ◽  
Case Series ◽  
Granulocytic Sarcoma ◽  
Leukemia Cells ◽  
Retrospective Case ◽  
Retrospective Case Series ◽  
The Central Nervous System

Abstract Introduction: Primary granulocytic sarcoma (PGS) is an extramedullary tumor of immature granulocytic cells without prior evidence of leukemia，it often develops to AML by months to years, carrying a poor prognosis. PGS that occur in cervix are rare. The case reports or retrospective case series about it are scarce too. The tumor may involve in any organ and there is no abnormality in bone marrow, so clinicians always confronted with diagnostic and therapeutic challenges. This abstract aims at assisting physicians precisely diagnosing the PGSC as soon as possible and may indicate the timely appropriate therapy which can reduce the risk progressing to AML. Methods: we retrospectively reviewed the database of PubMed and CNKI between January 2003 to May 2014, using the term “Myeloid sarcoma” or “Granulocytic sarcoma” or “Extramedullary Myeloid Cell Tumor” and “cervix”; we also evaluated potentially relevant reports referenced in retrospective case series and a case of PGSC diagnosed in our hospital. The patients’ age, initial and accompanied symptoms, pathological section and Immunohistochemical staining of the tumor, as well as the treatment and prognosis were analyzed. Results: There are 13 cases of the PGSC, 11 of which reported in China and 2 reported abroad. Their age range from 28 to 46 years; These PGSC cases had various presentations in the form of irregular vaginal bleeding (11/13), pain of underbelly (2/13),with other accompanied symptoms such as dyspareunia and increasing of leucorrhea. All the cases made definite diagnosis through pathology and a series of appropriate immunohistochemical panel of antibodies that includes myeloperoxidase, lysozyme,CD68,CD43,CD34,CD20,CD3,CD117,CD45;the tumor cells of all the 13 cases showed positive immunohistochemical reactivity with MPO and at least one of the myelocytic antigens (HLA-DR,CD34,CD117, etc) was expressed. The following antibodies: CD20, CD3 did not react in the neoplastic cells. Several of the cases be mistaken for lymphoma as the two may be indistinguishable on routine hematoxylin and eosin staining; PGS cells, nuclei are slightly smaller with more finely dispersed chromatin, and some cells may show recognizable myeloid differentiation. Most of them received systemic chemotherapy associated with AML, the induce chemotherapy included DA (6/14), IA (2/14), HA (1/14); 2 of the 14 patients received paclitaxel (TAX) combined with chemotherapy;3 patients underwent combination therapy united with operations, radiotherapy and chemotherapy. To prevent the leukemia localization of the central nervous system, the patient in our hospital received intrathecal injection (MTX+Ara-c+Dex), others in the reviewed literature not seen. She has finished her first combined chemotherapy and local radiotherapy of pelvic cavity. PET-CT after the fifth chemotherapy showed complete resolution of the disease site. After 6 months, BM examination showed progression to AML-2a. Leukemia cells were detected quantification of the WT1 and ABL showed 2.49×10^4;and ABL1 7.52×10^4.Leukemia cells were showed negative for AML/ETO1 and Flt-3. Other patients reported in the literature kept a leukemia-free survival state during the follow-up period ranged from 2 months to 6 years. Conclusions: Based on our review of the literature and the case diagnosed in our hospital, the majority of the PGSC patients are presented with vaginal or postcoital bleeding. When the tumor mass is observed in an unusual location without abnormal of hematology, many patients are misdiagnosed or never diagnosed. To make a precise diagnosis, the use of a series of appropriate immunohistochemical panel of antibodies that includes myeloperoxidase, lysozyme, CD68, CD43, CD34, CD20, CD3, however, can successfully identify the vast majority of PGSC. Besides, examinations such as BM aspiration, Cytogenetic, FISH tests and fusion gene were required to make sure whether it is accompanied with AML and monitor the minimal residual disease or indicate a poor risk category. As a systemic disease, combination therapy should united with operations, radiotherapy and chemotherapy, especially the early and intensive chemotherapy can improve prognosis and help to prevent or delay AML, HSCT is also recommended. To prevent the leukemia localization of the central nervous system, intrathecal injection may aid to patients’ longer survival. Disclosures No relevant conflicts of interest to declare.

MRI Findings of Central Nervous System Granulocytic Sarcoma (Chloroma)

1997 ◽  
Vol 36 (3) ◽  
pp. 369
Author(s):  
Chang Man Lee ◽  
Myung Soon Kim ◽  
Ik Soo Kim ◽  
Kwan Soo Cho
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Granulocytic Sarcoma ◽  
Mri Findings

Ovarian Granulocytic Sarcoma with Central Nervous System Involvement

1986 ◽  
Vol 72 (3) ◽  
pp. 335-338 ◽  
Author(s):  
Roberto Marra ◽  
Livio Pagano ◽  
Sergio Storti ◽  
Carla Rabitti ◽  
Raffaele Tartaglione ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Myeloid Leukemia ◽  
Clinical Course ◽  
Prognostic Significance ◽  
Central Nervous System Involvement ◽  
Granulocytic Sarcoma ◽  
Cns Involvement ◽  
Short Period ◽  
Acute Myeloid

The authors describe 2 cases of acute myeloid leukemia (AML) with ovarian granulocytic sarcoma (GS) and central nervous system (CNS) involvement. The patients had an unfavorable clinical course in a short period of time. It has been reported that GS or CNS involvement does not have a bad prognostic significance. We suggest that the association of these two complications worsens the prognosis of AML.

Neurotropic enteroviruses co-opt “fair-weather-friend” commensal gut microbiota to drive host infection and central nervous system disturbances

2019 ◽  
Vol 42 ◽  
Author(s):  
Kevin B. Clark
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gut Bacteria ◽  
Infection Cycle ◽  
Fair Weather ◽  
Host Health ◽  
Microbe Interactions ◽  
Animal Hosts ◽  
Host Infection ◽  
Neuropsychiatric Conditions

Abstract Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system (CNS) disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

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